Estimating past inhalation exposure to asbestos: a tool for risk attribution and disease screening

Introduction: Late presentation is common in mesothelioma. Reliable assessment of past exposure to asbestos is a necessary first step for risk attribution and for the development of a future screening programme. Such a programme could maximise access to trials of novel therapies and would pave the way for development of novel chemoprophylaxis strategies. This paper describes a method for individual exposure reconstruction along with data from a validation study. Methods: The exposure assessment method uses only descriptive information about the circumstances of the work that could be obtained from questioning the worker. The assessment is based on the tasks carried out and includes parameters for substance emission potential, activity emission potential, the effectiveness of any local control measures, passive emission, the fractional time the asbestos source is active and the efficiency of any respiratory protection worn. Results: There was a good association between the estimated and measured exposure levels. Pearson’s correlation coefficient between the log-transformed measurements and estimates from the model was 0.86, and 95% of the estimated individual values were within about a factor of ten of the associated measured value. The method described would be suitable for pre-selecting individuals at high risk of malignant pleural mesothelioma for screening using appropriate tools and/or enrolment in clinical trials of chemo-prophylaxis. Discussion: This method is of potential clinical value in developing novel treatment approaches for mesothelioma. Pilot studies to test this approach are urgently needed

Bug propagation and debugging in asymmetric software structures

Software dependence networks are shown to be scale-free and asymmetric. We then study how software components are affected by the failure of one of them, and the inverse problem of locating the faulty component. Software at all levels is fragile with respect to the failure of a random single component. Locating a faulty component is easy if the failures only affect their nearest neighbors, while it is hard if the failures propagate further.Comment: 4 pages, 4 figure

Effect of Loss on Multiplexed Single-Photon Sources

An on-demand single-photon source is a key requirement for scaling many optical quantum technologies. A promising approach to realize an on-demand single-photon source is to multiplex an array of heralded single-photon sources using an active optical switching network. However, the performance of multiplexed sources is degraded by photon loss in the optical components and the non-unit detection efficiency of the heralding detectors. We provide a theoretical description of a general multiplexed single-photon source with lossy components and derive expressions for the output probabilities of single-photon emission and multi-photon contamination. We apply these expressions to three specific multiplexing source architectures and consider their tradeoffs in design and performance. To assess the effect of lossy components on near- and long-term experimental goals, we simulate the multiplexed sources when used for many-photon state generation under various amounts of component loss. We find that with a multiplexed source composed of switches with ~0.2-0.4 dB loss and high efficiency number-resolving detectors, a single-photon source capable of efficiently producing 20-40 photon states with low multi-photon contamination is possible, offering the possibility of unlocking new classes of experiments and technologies.Comment: Journal versio

Violence brief interventions: a rapid review

Provision of a Violence Brief Intervention (VBI) to young men undergoing treatment for a violent injury may represent a teachable moment for the prevention of future interpersonal violence in Scotland. Prior to intervention design, a rapid review of the research literature was necessary to examine existing programmes. After title and abstract screening, eight distinct VBIs were identified from full texts. Whilst none of the programmes were a perfect match for our intervention goals, they did demonstrate the potential effectiveness of brief interventions for violence prevention at both cognitive and behavioural levels. Key themes of successful interventions included brief motivational interviewing as an effective method of engaging with at-risk participants and encouraging change, the utility of social norms approaches for correcting peer norm misperceptions, the usefulness of working with victims of violence in medical settings (particularly oral and maxillofacial surgeries), the importance of addressing the role of alcohol after violent injury, the advantages of a computer-therapist hybrid model of delivery, and the need for adequate follow-up evaluation as part of a randomised control trial. This information has been used to design a VBI which is currently under evaluation

Photon counting for quantum key distribution with Peltier cooled InGaAs/InP APD's

The performance of three types of InGaAs/InP avalanche photodiodes is investigated for photon counting at 1550 nm in the temperature range of thermoelectric cooling. The best one yields a dark count probability of $2.8\cdot 10^{-5}$ per gate (2.4 ns) at a detection efficiency of 10% and a temperature of -60C. The afterpulse probability and the timing jitter are also studied. The results obtained are compared with those of other papers and applied to the simulation of a quantum key distribution system. An error rate of 10% would be obtained after 54 kilometers.Comment: 8 pages, 10 figures, submitted to Journal of Modern Optic

Quantum cosmology of a classically constrained nonsingular Universe

The quantum cosmological version of a nonsingular Universe presented by Mukhanov and Brandenberger in the early nineties has been developed and the Hamilton Jacobi equation has been found under semiclassical (WKB) approximation. It has been pointed out that, parameterization of classical trajectories with semiclassical time parameter, for such a classically constrained system, is a nontrivial task and requires Lagrangian formulation rather than the Hamiltonian formalism.Comment: 15 page

Bluetongue virus infection creates light averse Culicoides vectors and serious errors in transmission risk estimates.

BackgroundPathogen manipulation of host behavior can greatly impact vector-borne disease transmission, but almost no attention has been paid to how it affects disease surveillance. Bluetongue virus (BTV), transmitted by Culicoides biting midges, is a serious disease of ruminant livestock that can cause high morbidity and mortality and significant economic losses. Worldwide, the majority of surveillance for Culicoides to assess BTV transmission risk is done using UV-light traps. Here we show that field infection rates of BTV are significantly lower in midge vectors collected using traps baited with UV light versus a host cue (CO2).MethodsWe collected Culicoides sonorensis midges in suction traps baited with CO2, UV-light, or CO2 + UV on three dairies in southern California to assess differences in the resulting estimated infection rates from these collections. Pools of midges were tested for BTV by qRT-PCR, and maximum likelihood estimates of infection rate were calculated by trap. Infection rate estimates were also calculated by trapping site within a dairy. Colonized C. sonorensis were orally infected with BTV, and infection of the structures of the compound eye was examined using structured illumination microscopy.ResultsUV traps failed entirely to detect virus both early and late in the transmission season, and underestimated virus prevalence by as much as 8.5-fold. CO2 + UV traps also had significantly lower infection rates than CO2-only traps, suggesting that light may repel infected vectors. We found very high virus levels in the eyes of infected midges, possibly causing altered vision or light perception. Collecting location also greatly impacts our perception of virus activity.ConclusionsBecause the majority of global vector surveillance for bluetongue uses only light-trapping, transmission risk estimates based on these collections are likely severely understated. Where national surveillance programs exist, alternatives to light-trapping should be considered. More broadly, disseminated infections of many arboviruses include infections in vectors' eyes and nervous tissues, and this may be causing unanticipated behavioral effects. Field demonstrations of pathogen-induced changes in vector behavior are quite rare, but should be studied in more systems to accurately predict vector-borne disease transmission

Investigation into the voltammetric behaviour and detection of selenium(IV) at metal electrodes in diverse electrolyte media

The voltammetric behaviour of selenium(IV) was studied at platinum and gold electrodes in sulphuric acid, perchloric acid and potassium chloride media as a basis for its voltammetric detection. The best voltammetric behaviour was recorded at gold electrodes with perchloric acid as the supporting electrolyte. The concomitant presence of metals, such as copper or lead, and of model biomolecules, such as bovine serum albumin, in the solution resulted in a deterioration of the electrochemical response for selenium(IV). Quantitative detection of selenium(IV) by square wave anodic stripping voltammetry at both a millimetre-sized gold disc electrode and a microband electrode array revealed linear responses to selenium concentration in the ranges of 5-15 μM and 0.1-10 μM, respectively, with 60 s preconcentration. The sensitivities were 6.4 μA μM-1 cm-2 and 100 μA μM-1 cm-2 at the disc and the microband array, respectively. The detection limit at the microband electrode array was 25 nM, illustrating the potentiality of such microelectrodes for the development of mercury-free analytical methods for the trace detection of selenium(IV)